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Below are the 天发娱乐棋牌_天发娱乐APP-官网|下载 Clinical and Experimental Neurology Team's research studies?related to brain haemorrhage.
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Non-visible deficits after subarachnoid haemorrhage
Many people with lived experience of subarachnoid haemorrhage cannot return to their previous level of functioning, despite looking outwardly well. This is due to a number of non-visible deficits which impact quality of life and productivity, such as cognition, hearing difficulty, headache and fatigue. Ongoing work is focusing on other such non-visible deficits.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载.
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Haptoglobin as a treatment after subarachnoid haemorrhage
Haptoglobin is a natural protein which binds haemoglobin and can protect the brain from haemoglobin toxicity. We have demonstrated proof-of-concept that haptoglobin prevents the deleterious effect of haemoglobin in neuronal cultures and in a mouse model. Further studies are ongoing to prepare for Phase I clinical trial.
Funded by the Engineering and Physical Sciences Research Council, Guarantors of Brain?and Kedrion.
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Genome-wide association study (GWAS)?of outcome after subarachnoid haemorrhage
Studying the genetic determinants of clinical outcome after subarachnoid haemorrhage in order to identify novel therapeutic targets and improve current prognostic algorithms. This is an international study of the HATCH consortium, led from the University of 天发娱乐棋牌_天发娱乐APP-官网|下载. A preliminary exploratory study using already available genotype data has shown exciting results, recruitment of cases continues and we are currently seeking funding to type 7,000 cases from the consortium.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载, Guarantors of Brain?and Rosetrees Trust.
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Proteomic and metabolomic correlates of outcome after subarachnoid haemorrhage
Studying the biochemical signatures in blood and cerebrospinal fluid at protein and metabolite levels, correlating with outcome, with two aims: (1) discovery of therapeutic targets (2) prognostication.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载,?Wessex Medical Research?and Ferblanc.
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Prevention of aneurysmal rupture
Subarachnoid haemorrhage is most often the result of rupture of a swelling on a cerebral artery called an aneurysm. Identifying modifiable risk factors for aneurysmal formation and rupture is key. Enhanced aneurysmal rupture prediction models would better inform the clinical need for surgery to remove the aneurysm. We are undertaking histological and imaging studies of ruptured and unruptured aneurysms to determine the underyling mechanisms leading to rupture.?
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载?and the?National Institute for Health and Care Research.
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Haemoglobin scavenging kinetics in the brain after subarachnoid haemorrhage
Haemoglobin is neurotoxic once outside red blood cells. Treatments to improve haemoglobin clearance from the brain after haemorrhage may be possible. We are studying the kinetics of haemoglobin clearance to define the limits of the therapeutic window.
Funded by the Medical Research Council.
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Sulphoradex After Subarachnoid haemorrhage (SAS) study
A randomized controlled study of a stable formulation of sulforaphane after subarachnoid haemorrhage (see protocol and results).
Funded by Evgen.
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Haptoglobin genotype and long-term clinical outcome after aneurysmal subarachnoid haemorrhage
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after subarachnoid haemorrhage. With over 1000 participants, this is the largest single study examining this issue.
Funded by the Medical Research Council.
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Haptoglobin genotype and outcome after intracerebral haemorrhage
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after intracerebral haemorrhage. Initial findings are published in the journal JNNP.
Funded by the Medical Research Council.
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SubArachnoid Haemorrhage Outcome Tool (SAHOT)
Developing a clinical outcome tool specific for subarachnoid haemorrhage, published in Brain. It is being translated into seven languages and current work is aiming to develop the tools to facilitate its clinical deployment.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载?and the?National Institute for Health and Care Research.
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Hearing difficulty after subarachnoid haemorrhage
We have discovered that hearing loss affects a significant proportion of survivors after subarachnoid haemorrhage, and is characterized as a central auditory processing disorder. We?have worked out the underlying mechanism of development of this hearing difficulty, have confirmed its relationship with cognitive outcomes in a UK Biobank study, provided proof-of-concept that an assistive listening device improves hearing, and are currently planning a randomised controlled trial.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载.
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A neuropathological study of the haemoglobin scavenging system after subarachnoid haemorrhage
To understand how haemoglobin is cleared from the brain, using post-mortem specimens from people after subarachnoid haemorrhage and control individuals. We have made seminal observations regarding the deposition of iron in the cortex?after subarachnoid haemorrhage; further studies are ongoing.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载.
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Haptoglobin genotype and outcome after subarachnoid haemorrhage
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after subarachnoid haemorrhage. This is an international collaboration to enable an individual patient level data analysis of data in small published and unpublished studies, which has been completed. An update of a meta-analysis of published studies is ongoing.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载.
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Haptoglobin genotype and outcome after sepsis
Haptoglobin exists in two forms which might differ in how this protein affects clinical outcome after sepsis.
Funded by the University of 天发娱乐棋牌_天发娱乐APP-官网|下载.
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