Publications

Browse our publications catalogue to learn about our research.

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

S. Drennan, A. D'Avola, Y. Gao, C. Weigel, E. Chrysostomou, A.J. Steele, T. Zenz, C. Plass, P.W. Johnson, A.P. Williams, G. Packham, F.K. Stevenson, C.C. Oakes & F. Forconi, 2017, Leukemia, 31(8), 1686-1694

DOI: 10.1038/leu.2016.356

Type: article

STING activation reverses lymphoma-mediated resistance to antibody immunotherapy

Lekh N Dahal, Lang Dou, Khiyam Hussain, Rena Liu, Alexander Earley, Kerry L Cox, Salome Murinello, Ian Tracy, Francesco Forconi, Andrew J Steele, Patrick Duriez, Diego Gomez-Nicola, Jessica L Teeling, Martin J Glennie, Mark S Cragg & Stephen A Beers, 2017, Cancer Research, 77(13), 3619-3631

DOI: 10.1158/0008-5472.CAN-16-2784

Type: article

The dual Syk/JAK inhibitor cerdulatinib antagonizes B-cell receptor and microenvironmental signaling in chronic lymphocytic leukemia

Matthew D. Blunt, Stefan Koehrer, Rachel C. Dobson, Marta Larrayoz, Sarah Wilmore, Alice Hayman, Jack Parnell, Lindsay D. Smith, Andrew Davies, Peter W.M. Johnson, Pamela B. Conley, Anjali Pandey, Jonathan C. Strefford, Freda K. Stevenson, Graham Packham, Francesco Forconi, Greg P Coffey, Jan A. Burger & Andrew J. Steele, 2017, Clinical Cancer Research, 23(9), 2313-2324

DOI: 10.1158/1078-0432.CCR-16-1662

Type: article

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

Matthew Carter, Kerry Cox, Stuart Blakemore, Anna Turaj, Robert Oldham, Lekh Dahal, Stacey Tannheimer, Francesco Forconi, Graham Packham & Mark Cragg, 2017, Leukemia, 31(6), 1423–1433

DOI: 10.1038/leu.2016.333

Type: article

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2alpha phosphorylation in established cell lines and primary human leukemia cells

Alison Yeomans, Elizabeth Lemm, Sarah Wilmore, Breeze Cavell, Beatriz Valle-Argos, Sergey Krysov, Marina Hidalgo, Elodie Leonard, Anne E. Willis, Francesco Forconi, Freda Stevenson, Andrew Steele, Mark Coldwell & Graham Packham, 2016, Oncotarget, 7(46), 74807-74819

DOI: 10.18632/oncotarget.11655

Type: article

Surface IgM expression and function associate with clinical behavior, genetic abnormalities and DNA methylation in CLL

Annalisa D'Avola, Samantha Drennan, Ian Tracy, Isla Henderson, Laura Chiecchio, Marta Larrayoz, Matthew Rose-Zerilli, Jonathan Strefford, Christoph Plass, Peter W. Johnson, Andrew J. Steele, Graham Packham, Freda K. Stevenson, Christopher C. Oakes & Francesco Forconi, 2016, Blood, 128(6), 816-826

DOI: 10.1182/blood-2016-03-707786

Type: article

IL-4 enhances expression and function of surface IgM in CLL cells

Maria M. Aguilar-Hernandez, Matthew Blunt, Rachel Dobson, Alison Yeomans, Stephen Thirdborough, Marta Larrayoz, Lindsay Smith, Adam Linley, Jonathan C. Strefford, Andrew Davies, Peter Johnson, Natalia Savelyeva, Mark Cragg, Francesco Forconi, Graham Packham, Freda K. Stevenson & Andrew J. Steele, 2016, Blood, 127(24), 3015-3025

DOI: 10.1182/blood-2015-11-682906

Type: article