Research project

Defining signalling networks in colorectal cancer

Lead researchers:

Professor Rob Ewing
Status:

Not active

Staff

Lead researchers

Professor Rob Ewing BSc(Hons), DPhil

Professor of Bioinformatics

Connect with Rob

Email: rob.ewing@soton.ac.uk

Research outputs

The USP7 protein interaction network and its roles in tumorigenesis

Ahood Al-Eidan, Yihua Wang, Paul Skipp & Rob M. Ewing, 2022, Genes and Diseases, 9(1), 41-50

DOI: 10.1016/j.gendis.2020.10.004

Type: review

ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer

Dian Liu, Ayse Ertay, Charlotte Hill, Yilu Zhou, Juanjuan Li, Yanmei Zou, Hong Qiu, Xianglin Yuan, Robert Ewing, Xin Lu, Hua Xiong & Yihua Wang, 2020, Cell Death and Disease, 11(4)

DOI: 10.1038/s41419-020-2415-2

Type: article

Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin

Emily H. Bowler, Alex Smith-Vidal, Alex Lester, Joseph Bell, Zhenghe Wang, Christopher Bell, Yihua Wang, Nullin Divecha, Paul Skipp & Rob M. Ewing, 2019, Epigenetics, 15(1-2), 107-121

DOI: 10.1080/15592294.2019.1656154

Type: article

Proteomic analysis of azacitidine-induced degradation profiles identifies multiple chromatin and epigenetic regulators including Uhrf1 and Dnmt1 as sensitive to azacitidine

Emily H. Bowler, Joseph Bell, Nullin Divecha, Paul Skipp & Rob M. Ewing, 2019, Journal of Proteome Research, 18(3), 1032-1042

DOI: 10.1021/acs.jproteome.8b00745

Type: article

ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1

D. Liu, Y. Skomorovska, J. Song, E. Bowler, R. Harris, M. Ravasz, S. Bai, M. Ayati, K. Tamai, M. Koyuturk, X. Yuan, Z. Wang, Y. Wang & R.M. Ewing, 2018, Cancer Biology & Therapy, 1-11

DOI: 10.1080/15384047.2018.1507256

Type: article

Multi-proteomic and transcriptomic analysis of oncogenic β-catenin molecular networks

Rob M. Ewing, Jing Song, Giridharan Gokulrangan, Sheldon Bai, Emily H. Bowler, Rachel Bolton, Paul Skipp, Yihua Wang & Zhenghe Wang, 2018, Journal of Proteome Research, 17(6), 2216-2225

DOI: 10.1021/acs.jproteome.8b00180

Type: article

How do oncoprotein mutations rewire protein–protein interaction networks?

Emily Bowler, Zhenghe Wang & Rob Ewing, 2015, Expert Review of Proteomics, 12(5), 449-455

DOI: 10.1586/14789450.2015.1084875

Type: article